The PDZ Binding Motif of Human Papillomavirus Type 16 E6 Induces PTPN13 Loss, Which Allows Anchorage-Independent Growth and Synergizes with Ras for Invasive Growth

The human papillomavirus (HPV) oncogene E6 has been shown to perform multiple functions (p53 degradation, telomerase activation, etc.) that play a role in oncogenic transformation. Beyond known E6 functions, an undefined mechanism that allows cellular invasion requires the E6 PDZ binding motif (PDZB...

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Autors principals: Spanos, William C., Hoover, Andrew, Harris, George F., Wu, Shu, Strand, Guinevere L., Anderson, Mary E., Klingelhutz, Aloysius J., Hendriks, Wiljan, Bossler, Aaron D., Lee, John H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Transformation and Oncogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258903/
https://ncbi.nlm.nih.gov/pubmed/18160445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02188-07
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