DOG-1 Is the Caenorhabditis elegans BRIP1/FANCJ Homologue and Functions in Interstrand Cross-Link Repair

Fanconi anemia (FA) is a cancer susceptibility syndrome characterized by defective DNA interstrand cross-link (ICL) repair. Here, we show that DOG-1 is the Caenorhabditis elegans homologue of FANCJ, a helicase mutated in FA-J patients. DOG-1 performs a conserved role in ICL repair, as dog-1 mutants...

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Autori principali: Youds, Jillian L., Barber, Louise J., Ward, Jordan D., Collis, Spencer J., O'Neil, Nigel J., Boulton, Simon J., Rose, Ann M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258786/
https://ncbi.nlm.nih.gov/pubmed/18086896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01641-07
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