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Chronic CD4(+) T-Cell Activation and Depletion in Human Immunodeficiency Virus Type 1 Infection: Type I Interferon-Mediated Disruption of T-Cell Dynamics

The mechanism of CD4(+) T-cell depletion during chronic human immunodeficiency virus type 1 (HIV-1) infection remains unknown. Many studies suggest a significant role for chronic CD4(+) T-cell activation. We assumed that the pathogenic process of excessive CD4(+) T-cell activation would be reflected...

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Bibliografiset tiedot
Päätekijät: Sedaghat, Ahmad R., German, Jennifer, Teslovich, Tanya M., Cofrancesco, Joseph, Jie, Chunfa C., Talbot, C. Conover, Siliciano, Robert F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258719/
https://ncbi.nlm.nih.gov/pubmed/18077723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02228-07
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