Residual Human Immunodeficiency Virus Type 1 Viremia in Some Patients on Antiretroviral Therapy Is Dominated by a Small Number of Invariant Clones Rarely Found in Circulating CD4(+) T Cells

Antiretroviral therapy can reduce human immunodeficiency virus type 1 (HIV-1) viremia to below the detection limit of ultrasensitive clinical assays (50 copies of HIV-1 RNA/ml). However, latent HIV-1 persists in resting CD4(+) T cells, and low residual levels of free virus are found in the plasma. L...

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Hauptverfasser: Bailey, Justin R., Sedaghat, Ahmad R., Kieffer, Tara, Brennan, Timothy, Lee, Patricia K., Wind-Rotolo, Megan, Haggerty, Christine M., Kamireddi, Ashrit R., Liu, Yi, Lee, Jessica, Persaud, Deborah, Gallant, Joel E., Cofrancesco, Joseph, Quinn, Thomas C., Wilke, Claus O., Ray, Stuart C., Siliciano, Janet D., Nettles, Richard E., Siliciano, Robert F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1488985/
https://ncbi.nlm.nih.gov/pubmed/16775332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00591-06
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