Residual Human Immunodeficiency Virus Type 1 Viremia in Some Patients on Antiretroviral Therapy Is Dominated by a Small Number of Invariant Clones Rarely Found in Circulating CD4(+) T Cells

Antiretroviral therapy can reduce human immunodeficiency virus type 1 (HIV-1) viremia to below the detection limit of ultrasensitive clinical assays (50 copies of HIV-1 RNA/ml). However, latent HIV-1 persists in resting CD4(+) T cells, and low residual levels of free virus are found in the plasma. L...

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Main Authors: Bailey, Justin R., Sedaghat, Ahmad R., Kieffer, Tara, Brennan, Timothy, Lee, Patricia K., Wind-Rotolo, Megan, Haggerty, Christine M., Kamireddi, Ashrit R., Liu, Yi, Lee, Jessica, Persaud, Deborah, Gallant, Joel E., Cofrancesco, Joseph, Quinn, Thomas C., Wilke, Claus O., Ray, Stuart C., Siliciano, Janet D., Nettles, Richard E., Siliciano, Robert F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1488985/
https://ncbi.nlm.nih.gov/pubmed/16775332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00591-06
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