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Functional transitions in myosin: Formation of a critical salt-bridge and transmission of effect to the sensitive tryptophan

For analyzing the mechanism of energy transduction in the “motor” protein, myosin, it is opportune both to model the structural change in the hydrolytic transition, ATP (myosin-bound) + H(2)O → ADP⋅P(i) (myosin-bound) and to check the plausibility of the model by appropriate site-directed mutations...

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Autori principali: Onishi, Hirofumi, Kojima, Shin-ichiro, Katoh, Kazuo, Fujiwara, Keigi, Martinez, Hugo M., Morales, Manuel F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC22585/
https://ncbi.nlm.nih.gov/pubmed/9618467
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