Transcriptional Regulation of PIK3CA Oncogene by NF-κB in Ovarian Cancer Microenvironment

PIK3CA upregulation, amplification and mutation have been widely reported in ovarian cancers and other tumors, which strongly suggests that PIK3CA is a promising therapeutic target. However, to date the mechanisms underlying PIK3CA regulation and activation in vivo is still unclear. During tumorigen...

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Detalhes bibliográficos
Main Authors: Yang, Nuo, Huang, Jia, Greshock, Joel, Liang, Shun, Barchetti, Andrea, Hasegawa, Kosei, Kim, Sarah, Giannakakis, Antonis, Li, Chunsheng, O'Brien-Jenkins, Anne, Katsaros, Dionyssios, Bützow, Ralf, Coukos, George, Zhang, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258145/
https://ncbi.nlm.nih.gov/pubmed/18335034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001758
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