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Structural basis for chemical inhibition of human blood coagulation factor Xa

Factor Xa, the converting enzyme of prothrombin to thrombin, has emerged as an alternative (to thrombin) target for drug discovery for thromboembolic diseases. An inhibitor has been synthesized and the crystal structure of the complex between Des[1–44] factor Xa and the inhibitor has been determined...

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Hlavní autoři: Kamata, Kenji, Kawamoto, Hiroshi, Honma, Teruki, Iwama, Toshiharu, Kim, Sung-Hou
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1998
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC22577/
https://ncbi.nlm.nih.gov/pubmed/9618463
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