Hypotension and inflammatory cytokine gene expression triggered by factor Xa–nitric oxide signaling

The signaling pathway initiated by factor Xa on vascular endothelial cells was investigated. Factor Xa stimulated a 5- to 10-fold increased release of nitric oxide (NO) in a dose-dependent reaction (0.1–2.5 μg/ml) unaffected by the thrombin inhibitor hirudin but abolished by active site inhibitors,...

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Hauptverfasser: Papapetropoulos, Andreas, Piccardoni, Paola, Cirino, Giuseppe, Bucci, Mariarosaria, Sorrentino, Raffaella, Cicala, Carla, Johnson, Kirk, Zachariou, Venetia, Sessa, William C., Altieri, Dario C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1998
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC22560/
https://ncbi.nlm.nih.gov/pubmed/9539808
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