Chromatin modifications induced by PML-RARα repress critical targets in leukemogenesis as analyzed by ChIP-Chip

The translocation t(15;17) generates the chimeric PML-RARα transcription factor that is the initiating event of acute promyelocytic leukemia. A global view of PML-RARα transcriptional functions was obtained by genome-wide binding and chromatin modification analyses combined with genome-wide expressi...

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Главные авторы: Hoemme, Claudia, Peerzada, Abdul, Behre, Gerhard, Wang, Yipeng, McClelland, Michael, Nieselt, Kay, Zschunke, Matthias, Disselhoff, Christine, Agrawal, Shuchi, Isken, Fabienne, Tidow, Nicola, Berdel, Wolfgang E., Serve, Hubert, Müller-Tidow, Carsten
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2008
Предметы:
Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254548/
https://ncbi.nlm.nih.gov/pubmed/18024792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-079921
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