Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor

Semaphorin 3A (Sema3A), a known inhibitor of axonal sprouting, also alters vascular patterning. Here we show that Sema3A selectively interferes with VEGF- but not bFGF-induced angiogenesis in vivo. Consistent with this, Sema3A disrupted VEGF- but not bFGF-mediated endothelial cell signaling to FAK a...

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Main Authors: Acevedo, Lisette M., Barillas, Samuel, Weis, Sara M., Göthert, Joachim R., Cheresh, David A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2008
Fag:
Hemostasis, Thrombosis, and Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254547/
https://ncbi.nlm.nih.gov/pubmed/18180379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-08-110205
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