Estimating effects of rare haplotypes on failure time using a penalized Cox proportional hazards regression model

BACKGROUND: This paper describes a likelihood approach to model the relation between failure time and haplotypes in studies with unrelated individuals where haplotype phase is unknown, while dealing with the problem of unstable estimates due to rare haplotypes by considering a penalized log-likeliho...

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Hlavní autoři: Souverein, Olga W, Zwinderman, Aeilko H, Jukema, J Wouter, Tanck, Michael WT
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
Methodology Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254440/
https://ncbi.nlm.nih.gov/pubmed/18221501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-9-9
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