A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes

BACKGROUND: The circadian expression of the mammalian clock genes is based on transcriptional feedback loops. Two basic helix-loop-helix (bHLH) PAS (for Period-Arnt-Sim) domain-containing transcriptional activators, CLOCK and BMAL1, are known to regulate gene expression by interacting with a promote...

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Bibliographic Details
Main Authors: Nakahata, Yasukazu, Yoshida, Mayumi, Takano, Atsuko, Soma, Haruhiko, Yamamoto, Takuro, Yasuda, Akio, Nakatsu, Toru, Takumi, Toru
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254435/
https://ncbi.nlm.nih.gov/pubmed/18177499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-9-1
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