The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skin

Polycyclic aromatic hydrocarbons (PAH) form stable and depurinating DNA adducts in mouse skin to induce preneoplastic mutations. Some mutations transform cells, which then clonally expand to establish tumors. Strong clues about the mutagenic mechanism can be obtained if the PAH-DNA adducts can be co...

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Main Authors: Chakravarti, Dhrubajyoti, Venugopal, Divya, Mailander, Paula C., Meza, Jane L., Higginbotham, Sheila, Cavalieri, Ercole L., Rogan, Eleanor G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2007
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254211/
https://ncbi.nlm.nih.gov/pubmed/17931959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2007.08.007
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