Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

There is increasing evidence that longevity and stress resistance are connected, but the mechanism is unclear. We report that mitochondria are regulated in response to oxidative stress and calorie restriction through a shared mechanism involving peroxisome proliferator-activated receptor-γ co-activa...

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Autori principali: Anderson, Rozalyn M, Barger, Jamie L, Edwards, Michael G, Braun, Kristina H, O’Connor, Clare E, Prolla, Tomas A, Weindruch, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2008
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253697/
https://ncbi.nlm.nih.gov/pubmed/18031569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2007.00357.x
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