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Design of HIV-1-PR inhibitors that do not create resistance: Blocking the folding of single monomers
The main problems found in designing drugs are those of optimizing the drug–target interaction and of avoiding the insurgence of resistance. We suggest a scheme for the design of inhibitors that can be used as leads for the development of a drug and that do not face either of these problems, and the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253289/ https://ncbi.nlm.nih.gov/pubmed/16195553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051670905 |
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