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Unfolding crystallins: The destabilizing role of a β-hairpin cysteine in βB2-crystallin by simulation and experiment
The thermodynamic and kinetic stabilities of the eye lens family of βγ-crystallins are important factors in the etiology of senile cataract. They control the chance of proteins unfolding, which can lead to aggregation and loss of transparency. βB2-Crystallin orthologs are of low stability and compri...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253261/ https://ncbi.nlm.nih.gov/pubmed/15840832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041227805 |
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