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Unfolding crystallins: The destabilizing role of a β-hairpin cysteine in βB2-crystallin by simulation and experiment

The thermodynamic and kinetic stabilities of the eye lens family of βγ-crystallins are important factors in the etiology of senile cataract. They control the chance of proteins unfolding, which can lead to aggregation and loss of transparency. βB2-Crystallin orthologs are of low stability and compri...

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Hlavní autoři: Macdonald, James T., Purkiss, Andrew G., Smith, Myron A., Evans, Paul, Goodfellow, Julia M., Slingsby, Christine
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253261/
https://ncbi.nlm.nih.gov/pubmed/15840832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041227805
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