Arginine-140 and isoleucine-141 determine the 17β-estradiol-binding specificity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma

Arginine-140 and isoleucine-141 were identified as key determinants of 17β-estradiol (E(2)) binding affinity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma. Amino acid residues that differ between human and rabbit SBP sequences were replaced in the human protein and the products t...

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Main Authors: Petra, Philip H., Adman, Elinor T., Orr, William R., Woodcock, Katherine T., Groff, Christine, Sui, Li-Ming
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253199/
https://ncbi.nlm.nih.gov/pubmed/11514672
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