Mutations Affecting DNA-Binding Activity of the MexR Repressor of mexR-mexA-mexB-oprM Operon Expression

We have isolated 25 MexR mutants that retained their dimerizing ability but were unable to bind mexOP DNA. Surprisingly, 20 mutations were located in the hydrophobic core region at α4, W1, α2, α3, and β2, and only 3 were in positively charged residues. These results verified that DNA binding is medi...

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Библиографические подробности

Опубликовано в::	J Bacteriol
Главные авторы:	Saito, Kohjiro, Akama, Hiroyuki, Yoshihara, Eisaku, Nakae, Taiji
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 2003
Предметы:	Gene Regulation
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC225045/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14526032/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.185.20.6195-6198.2003
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