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In Vitro Proteolytic Processing of the MD145 Norovirus ORF1 Nonstructural Polyprotein Yields Stable Precursors and Products Similar to Those Detected in Calicivirus-Infected Cells

The MD145-12 strain (GII/4) is a member of the genus Norovirus in the Caliciviridae and was detected in a patient with acute gastroenteritis in a Maryland nursing home. The open reading frame 1 (ORF1) (encoding the nonstructural polyprotein) was cloned as a consensus sequence into various expression...

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Autori principali: Belliot, Gaël, Sosnovtsev, Stanislav V., Mitra, Tanaji, Hammer, Carl, Garfield, Mark, Green, Kim Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC224964/
https://ncbi.nlm.nih.gov/pubmed/14512545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.20.10957-10974.2003
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