Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero

Two B-type cyclins, B1 and B2, have been identified in mammals. Proliferating cells express both cyclins, which bind to and activate p34(cdc2). To test whether the two B-type cyclins have distinct roles, we generated lines of transgenic mice, one lacking cyclin B1 and the other lacking cyclin B2. Cy...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Brandeis, Michael, Rosewell, Ian, Carrington, Mark, Crompton, Tessa, Jacobs, Mary Ann, Kirk, Jane, Gannon, Julian, Hunt, Tim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22491/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9539739/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.8.4344
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