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Mutation of the Cyba gene encoding p22(phox) causes vestibular and immune defects in mice
In humans, hereditary inactivation of either p22(phox) or gp91(phox) leads to chronic granulomatous disease (CGD), a severe immune disorder characterized by the inability of phagocytes to produce bacteria-destroying ROS. Heterodimers of p22(phox) and gp91(phox) proteins constitute the superoxide-pro...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2248803/ https://ncbi.nlm.nih.gov/pubmed/18292807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33835 |
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