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Mutation of the Cyba gene encoding p22(phox) causes vestibular and immune defects in mice

In humans, hereditary inactivation of either p22(phox) or gp91(phox) leads to chronic granulomatous disease (CGD), a severe immune disorder characterized by the inability of phagocytes to produce bacteria-destroying ROS. Heterodimers of p22(phox) and gp91(phox) proteins constitute the superoxide-pro...

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Detalhes bibliográficos
Main Authors: Nakano, Yoko, Longo-Guess, Chantal M., Bergstrom, David E., Nauseef, William M., Jones, Sherri M., Bánfi, Botond
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248803/
https://ncbi.nlm.nih.gov/pubmed/18292807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33835
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