Expression of a “Self-” Antigen by Human Tumor Cells Enhances Tumor Antigen-specific CD4(+) T-Cell Function

CD4(+) T cells can recognize “self” tumor antigens, but the impact of tumor cell expression of self-antigens on CD4(+) T-cell function in humans is unknown. Here, we identify a new epitope (ISPNSVFSQWRVVCDSLEDYD) derived from tyrosinase-related protein-1 (TRP-1) using a predictive algorithm and mice...

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Main Authors: Touloukian, Christopher E., Leitner, Wolfgang W., Robbins, Paul F., Li, Yong F., Kang, Xiaoqiang, Lapointe, Rejean, Hwu, Patrick, Rosenberg, Steven A., Restifo, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248802/
https://ncbi.nlm.nih.gov/pubmed/12234976
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