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Mutation of the arginine finger in the active site of Escherichia coli DbpA abolishes ATPase and helicase activity and confers a dominant slow growth phenotype

Escherichia coli DEAD-box protein A (DbpA) is an ATP-dependent RNA helicase with specificity for 23S ribosomal RNA. Although DbpA has been extensively characterized biochemically, its biological function remains unknown. Previous work has shown that a DbpA deletion strain is viable with little or no...

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Autores principales: Elles, Lisa M. Sharpe, Uhlenbeck, Olke C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248767/
https://ncbi.nlm.nih.gov/pubmed/17986459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm926
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