SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains

Mechanisms of gene repression by transforming growth factor-beta (TGF-beta) are not well understood. TGF-beta represses transcription of pulmonary surfactant protein-B gene in lung epithelial cells. Repression is mediated by SMAD3 through interactions with NKX2.1 and FOXA1, two key transcription fac...

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Detalhes bibliográficos
Main Authors: Minoo, Parviz, Hu, Lingyan, Zhu, Nianling, Borok, Zea, Bellusci, Saverio, Groffen, John, Kardassis, Dimitris, Li, Changgong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248754/
https://ncbi.nlm.nih.gov/pubmed/18003659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm871
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