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Calmodulin Regulation of Na(V)1.4 Current: Role of Binding to the Carboxyl Terminus

Calmodulin (CaM) regulates steady-state inactivation of sodium currents (Na(V)1.4) in skeletal muscle. Defects in Na current inactivation are associated with pathological muscle conditions such as myotonia and paralysis. The mechanisms of CaM modulation of expression and function of the Na channel a...

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Autori principali: Biswas, Subrata, Deschênes, Isabelle, DiSilvestre, Deborah, Tian, Yanli, Halperin, Victoria L., Tomaselli, Gordon F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248716/
https://ncbi.nlm.nih.gov/pubmed/18270170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200709863
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