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Purification and bioactivity of exendin-4, a peptide analogue of GLP-1, expressed in Pichia pastoris
Exendin-4, a peptide analogue of glucagon-like peptide-1 (GLP-1), has been developed for treatment of type 2 diabetes. Herein, the secretive exendin-4 fusion protein, expressed by methanol induction in Pichia pastoris system, was purified to homogeneity by chromatography followed by enterokinase cle...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Netherlands
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2248218/ https://ncbi.nlm.nih.gov/pubmed/18060365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10529-007-9610-4 |
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