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Self-excision of the BAC sequences from the recombinant Marek's disease virus genome increases replication and pathogenicity

Cloning of full length genomes of herpesviruses as bacterial artificial chromosomes (BAC) has greatly facilitated the manipulation of the genomes of several herpesviruses to identify the pathogenic determinants. We have previously reported the construction of the BAC clone (pRB-1B5) of the highly on...

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Detalhes bibliográficos
Main Authors: Zhao, Yuguang, Petherbridge, Lawrence, Smith, Lorraine P, Baigent, Sue, Nair, Venugopal
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248170/
https://ncbi.nlm.nih.gov/pubmed/18230192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-5-19
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