Enhanced cytostatic activity of the sesquiterpene lactone eupatoriopicrin by glutathione depletion.

Eupatoriopicrin (EUP), a sesquiterpene lactone from Eupatorium cannabinum L., possesses cytostatic activity. This was demonstrated for FIO 26 cells in vitro with the aid of a clonogenic assay and in vivo by tumour growth delay in FIO 26 and Lewis lung tumour-bearing mice. In vitro the IC50 for 1 h e...

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Main Authors: Woerdenbag, H. J., Lemstra, W., Malingré, T. M., Konings, A. W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246971/
https://ncbi.nlm.nih.gov/pubmed/2757925
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