Modulation in vitro and in vivo of cytotoxicity but not cellular levels of doxorubicin by the calmodulin inhibitor trifluoperazine is dependent on the level of resistance.

The role of the calmodulin inhibitor trifluoperazine (TFP) in modulating the cellular levels and cytotoxicity in vitro and antitumour effects in vivo of doxorubicin (DOX), was evaluated in progressively DOX-resistant (5- to 40-fold) sublines of B16-BL6 mouse melanoma. In parental-sensitive B16-BL6 c...

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Hauptverfasser: Ganapathi, R., Schmidt, H., Grabowski, D., Melia, M., Ratliff, N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1988
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246592/
https://ncbi.nlm.nih.gov/pubmed/3179186
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