Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3’ untranslated region (3’-UTR) or by exchange of the DENV-3 3’-UTR with that of DENV-4

The dengue virus type 3 (DENV-3) vaccine candidate, rDEN3Δ30, was previously found to be under-attenuated in both SCID-HuH-7 mice and rhesus monkeys. Herein, two strategies have been employed to generate attenuated rDEN3 vaccine candidates which retain the full complement of structural and nonstruct...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Blaney, Joseph E., Sathe, Neeraj S., Goddard, Laura, Hanson, Christopher T., Romero, Tammy A., Hanley, Kathryn A., Murphy, Brian R., Whitehead, Stephen S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246307/
https://ncbi.nlm.nih.gov/pubmed/18191005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2007.11.082
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge