A new computational approach to analyze human protein complexes and predict novel protein interactions

We propose a new approach to identify interacting proteins based on gene expression data. By using hypergeometric distribution and extensive Monte-Carlo simulations, we demonstrate that looking at synchronous expression peaks in a single time interval is a high sensitivity approach to detect co-regu...

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Detalhes bibliográficos
Main Authors: Zanivan, Sara, Cascone, Ilaria, Peyron, Chiara, Molineris, Ivan, Marchio, Serena, Caselle, Michele, Bussolino, Federico
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246258/
https://ncbi.nlm.nih.gov/pubmed/18053208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-12-r256
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