Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study

Proteinase-activated receptors (PARs) belong to a family of G protein-coupled receptors. PARs are activated by a serine-dependent cleavage generating a tethered activating ligand. PAR-2 was shown to be involved in inflammatory pathways. We investigated the in situ levels and modulation of PAR-2 in h...

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Detalhes bibliográficos
Main Authors: Boileau, Christelle, Amiable, Nathalie, Martel-Pelletier, Johanne, Fahmi, Hassan, Duval, Nicolas, Pelletier, Jean-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246240/
https://ncbi.nlm.nih.gov/pubmed/18031579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2329
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