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The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences Between Homologous Domains
Calmodulin (CaM) regulates tetrameric N-methyl-D-aspartate Receptors (NMDARs) by binding tightly to the C0 and C1 regions of its NR1 subunit. A crystal structure (2hqw; 1.96 Å) of calcium-saturated CaM bound to NR1C1 (peptide spanning 875–898) showed that NR1 S890, whose phosphorylation regulates me...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2246159/ https://ncbi.nlm.nih.gov/pubmed/18073110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.10.012 |
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