Magnitude and Diversity of Cytotoxic-T-Lymphocyte Responses Elicited by Multiepitope DNA Vaccination in Rhesus Monkeys

In an effort to develop an AIDS vaccine that elicits high-frequency cytotoxic-T-lymphocyte (CTL) responses with specificity for a diversity of viral epitopes, we explored two prototype multiepitope plasmid DNA vaccines in the simian-human immunodeficiency virus/rhesus monkey model to determine their...

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Main Authors: Subbramanian, Ramu A., Kuroda, Marcelo J., Charini, William A., Barouch, Dan H., Costantino, Cristina, Santra, Sampa, Schmitz, Jörn E., Martin, Kristi L., Lifton, Michelle A., Gorgone, Darci A., Shiver, John W., Letvin, Norman L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC224609/
https://ncbi.nlm.nih.gov/pubmed/12941922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.18.10113-10118.2003
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