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Catalysis of imido-group hydrolysis in a maleimide conjugate
Maleimides are often used for biomolecular conjugation with thiols. An underappreciated aspect of the imido group in a maleimide conjugate is its susceptibility to spontaneous hydrolysis, resulting in undesirable heterogeneity. Here, a chromophoric maleimide is used to demonstrate that both molybdat...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2245990/ https://ncbi.nlm.nih.gov/pubmed/17881230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.09.002 |
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