Specific Inhibition of the Synthesis of Human Lysyl-tRNA Synthetase Results in Decreases in tRNA(Lys) Incorporation, [Formula: see text] Annealing to Viral RNA, and Viral Infectivity in Human Immunodeficiency Virus Type 1

The major human tRNA(Lys) isoacceptors, [Formula: see text] and [Formula: see text] , are selectively packaged into human immunodeficiency virus type 1 (HIV-1) during assembly, where [Formula: see text] acts as a primer for reverse transcription. Lysyl-tRNA synthetase (LysRS) is also incorporated in...

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Detalhes bibliográficos
Main Authors: Guo, Fei, Cen, Shan, Niu, Meijuan, Javanbakht, Hassan, Kleiman, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC224598/
https://ncbi.nlm.nih.gov/pubmed/12941890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.18.9817-9822.2003
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