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Disruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2α kinase homolog

Phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) is a common cellular mechanism to limit protein synthesis in stress conditions. Baculovirus PK2, which resembles the C-terminal half of a protein kinase domain, was found to inhibit both human and yeast eIF2α kinases. Insect cell...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Dever, Thomas E., Sripriya, Rajaraman, McLachlin, Jeanne R., Lu, Jingfang, Fabian, John R., Kimball, Scot R., Miller, Lois K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22459/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9539707/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.8.4164
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