Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

High activity of histone deacetylases (HDACs) causes epigenetic alterations associated with malignant cell behaviour. Consequently, HDAC inhibitors have entered late-phase clinical trials as new antineoplastic drugs. However, little is known about expression and function of specific HDAC isoforms in...

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Bibliografske podrobnosti
Main Authors: Weichert, W, Röske, A, Gekeler, V, Beckers, T, Stephan, C, Jung, K, Fritzsche, F R, Niesporek, S, Denkert, C, Dietel, M, Kristiansen, G
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
Teme:
Molecular Diagnostics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2243142/
https://ncbi.nlm.nih.gov/pubmed/18212746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604199
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