Comparative crystallization and preliminary X-ray diffraction studies of locked nucleic acid and RNA stems of a tenascin C-binding aptamer

The pharmacokinetic properties of an aptamer against the tumour-marker protein tenascin-C have recently been successfully improved by the introduction of locked nucleic acids (LNAs) into the terminal stem of the aptamer. Since it is believed that this post-SELEX optimization is likely to provide a m...

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Bibliografiska uppgifter
Huvudupphovsmän: Förster, Charlotte, Brauer, Arnd B. E., Brode, Svenja, Schmidt, Kathrin S., Perbandt, Markus, Meyer, Arne, Rypniewski, Wojciech, Betzel, Christian, Kurreck, Jens, Fürste, Jens P., Erdmann, Volker A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Union of Crystallography 2006
Ämnen:
Crystallization Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242942/
https://ncbi.nlm.nih.gov/pubmed/16820689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309106020343
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