Purification, crystallization and X-ray diffraction analysis of human synaptotagmin 1 C2A-C2B

Synaptotagmin acts as the Ca(2+) sensor for neuronal exocytosis. The cytosolic domain of human synaptotagmin 1 is composed of tandem C2 domains: C2A and C2B. These C2 domains modulate the interaction of synaptotagmin with the phospholipid bilayer of the presynaptic terminus and effector proteins suc...

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Bibliographic Details
Main Authors: Montes, Miguel, Fuson, Kerry L., Sutton, R. Bryan, Robert, J. Justin
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2006
Subjects:
Crystallization Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242877/
https://ncbi.nlm.nih.gov/pubmed/16946482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309106029253
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