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A human mutation in Phox2b causes lack of CO(2) chemosensitivity, fatal central apnea, and specific loss of parafacial neurons

Breathing is maintained and controlled by a network of neurons in the brainstem that generate respiratory rhythm and provide regulatory input. Central chemoreception, the mechanism for CO(2) detection that provides an essential stimulatory input, is thought to involve neurons located near the medull...

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Main Authors: Dubreuil, Véronique, Ramanantsoa, Nélina, Trochet, Delphine, Vaubourg, Vanessa, Amiel, Jeanne, Gallego, Jorge, Brunet, Jean-François, Goridis, Christo
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242699/
https://ncbi.nlm.nih.gov/pubmed/18198276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709115105
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