Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity

Androgens exert their effects by binding to the highly specific androgen receptor (AR). In addition to natural potent androgens, AR binds a variety of synthetic agonist or antagonist molecules with different affinities. To identify molecular determinants responsible for this selectivity, we have det...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pereira de Jésus-Tran, Karine, Côté, Pierre-Luc, Cantin, Line, Blanchet, Jonathan, Labrie, Fernand, Breton, Rock
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2006
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242507/
https://ncbi.nlm.nih.gov/pubmed/16641486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051905906
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