Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

Improving the affinity of a high-affinity protein–protein interaction is a challenging problem that has practical applications in the development of therapeutic biomolecules. We used a combination of structure-based computational methods to optimize the binding affinity of an antibody fragment to th...

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Autors principals: Clark, Louis A., Boriack-Sjodin, P. Ann, Eldredge, John, Fitch, Christopher, Friedman, Bethany, Hanf, Karl J.M., Jarpe, Matthew, Liparoto, Stefano F., Li, You, Lugovskoy, Alexey, Miller, Stephan, Rushe, Mia, Sherman, Woody, Simon, Kenneth, Van Vlijmen, Herman
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242497/
https://ncbi.nlm.nih.gov/pubmed/16597831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.052030506
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