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Stabilization of a binary protein complex by intein-mediated cyclization

The study of protein–protein interactions can be hampered by the instability of one or more of the protein complex components. In this study, we showed that intein-mediated cyclization can be used to engineer an artificial intramolecular cyclic protein complex between two interacting proteins: the l...

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Detalhes bibliográficos
Main Authors: Jeffries, Cy M., Graham, Stephen C., Stokes, Philippa H., Collyer, Charles A., Guss, J. Mitchell, Matthews, Jacqueline M.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242402/
https://ncbi.nlm.nih.gov/pubmed/17001033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062377006
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