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Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models
BACKGROUND: Entolimod is a Salmonella enterica flagellin derivate. Previous work has demonstrated that entolimod effectively protects mice and non-human primates from ionizing radiation. However, it caused a “flu-like” syndrome after radioprotective and anticancer clinical application, indicating so...
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| Pubblicato in: | PeerJ |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
PeerJ Inc.
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6011820/ https://ncbi.nlm.nih.gov/pubmed/29938138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.5043 |
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