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An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry

The ability of proteins to regulate their own enzymatic activity can be facilitated by changes in structure or protein dynamics in response to external regulators. Because many proteins contain SH2 and SH3 domains, transmission of information between the domains is a potential method of allosteric r...

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מידע ביבליוגרפי
Main Authors: Hochrein, James M., Lerner, Edwina C., Schiavone, Anthony P., Smithgall, Thomas E., Engen, John R.
פורמט: Artigo
שפה:Inglês
יצא לאור: Cold Spring Harbor Laboratory Press 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242359/
https://ncbi.nlm.nih.gov/pubmed/16322569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051782206
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