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Efficient siRNA selection using hybridization thermodynamics
Small interfering RNA (siRNA) are widely used to infer gene function. Here, insights in the equilibrium of siRNA-target hybridization are used for selection of efficient siRNA. The accessibilities of siRNA and target mRNA for hybridization, as measured by folding free energy change, are shown to be...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2241856/ https://ncbi.nlm.nih.gov/pubmed/18073195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm920 |
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