Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

Deficiency in genes involved in DNA mismatch repair increases susceptibility to cancer, particularly of the colorectal epithelium. Using Msh2 null mice, we demonstrate that this genetic defect renders normal intestinal epithelial cells susceptible to mutation in vivo at the Dlb-1 locus. Compared wit...

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Detalhes bibliográficos
Main Authors: Toft, Neil J., Winton, Douglas J., Kelly, Jane, Howard, Louise A., Dekker, Marleen, te Riele, Hein, Arends, Mark J., Wyllie, Andrew H., Margison, Geoffrey P., Clarke, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22394/
https://ncbi.nlm.nih.gov/pubmed/10097137
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