Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity

The bacterial peroxiredoxin AhpC, a cysteine-dependent peroxidase, can be converted through a single amino acid insertion to a disulfide reductase, AhpC*, active in the glutathione and glutaredoxin pathway. Here we show that, whereas AhpC* is inactive as a peroxidase, other point mutants in AhpC can...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yamamoto, Yuji, Ritz, Dani, Planson, Anne-Gaëlle, Jönsson, Thomas J., Faulkner, Melinda J., Boyd, Dana, Beckwith, Jon, Poole, Leslie B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2239235/
https://ncbi.nlm.nih.gov/pubmed/18206967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.11.029
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